Persnickety definition in American English Fussy significance is reasonably elusive. It refers to someone who is immensely picky and judgmental. A persnickety individual often be fastidious and does not settle for less when it comes to expectations and flawlessness. Their fastidious nature can be seen as admirable, but it can also intensify overly demanding censure and unnecessary dissatisfaction. Being persnickety is often connected with thorough attention to detail but can also be seen as a form of perfectionism.